QL Secondary Structure Prediction
Using Homologues
Must get rid of the header and footer: leave only the alignments
Assumes that the first fragment is the longest fragment
(so as to know how many gaps to pad the ends of shorter fragments)
Arbitrary white spaces in between aligned fragments
Maximum of
70
homologues
Maximum of
2000
residues per fragment
Gaps are represented by '
-
' (hyphens)
End gaps are automatically added to short proteins
Characters b,j,o,u,x, and z are treated as unknown residues
The following is an example of the appropriate format:
You can save the results as plain text by clicking on the link at the bottom of the results page (loading the plain text up on another page), then using the save option on your web browser
OUTPUT format:
All 3 probabilities
Predicted sec. structure
Predicted sec. structure w/ prob.
Eye-Friendly: Seq. followed by prediction in rows
INPUT format:
BLAST output
Type in your alignment here:
sp|P15093|DYR_HALVO DIHYDROFOLATE REDUCTASE. pir||A34429 dihydrofolate reductase (EC 1.5.1.3) - Haloferax volcanii gi|148761 (J05088) dihydrofolate reductase [Halobacterium volcanii] Length = 162 Score = 751 (341.4 bits), Expect = 1.6e-98, P = 1.6e-98 Identities = 150/162 (92%), Positives = 150/162 (92%) Query: 1 MELVSVAALAENRVIGRDGELPWPSIPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSA 60 MELVSVAALAENRVIGRDGELPWPSIPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSA Sbjct: 1 MELVSVAALAENRVIGRDGELPWPSIPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSA 60 Query: 61 QIVMSRSERSFSVDTAHRAASVEEAVDIAASLDAETAYVIGGAAIYALFQPHLDRMVLSR 120 QIVMSRSERSFSVDTAHRAASVEEAVDIAASLDAETAYVIGGAAIYALFQPHLDRMVLSR Sbjct: 61 QIVMSRSERSFSVDTAHRAASVEEAVDIAASLDAETAYVIGGAAIYALFQPHLDRMVLSR 120 Query: 121 VPGEYEGDTYYPXXXXXXXXXXXXTDHEGFTLQEWVRSASSR 162 VPGEYEGDTYYP TDHEGFTLQEWVRSASSR Sbjct: 121 VPGEYEGDTYYPEWDAAEWELDAETDHEGFTLQEWVRSASSR 162 sp|P12833|DYR3_SALTY DIHYDROFOLATE REDUCTASE TYPE III. pir||RDEBDT dihydrofolate reductase (EC 1.5.1.3) type III - Salmonella typhimurium plasmid pAZ1 gi|150520 (J03306) dihydrofolate reductase type III [Plasmid pAZ1] Length = 162 Score = 94 (42.7 bits), Expect = 1.1e-28, Sum P(3) = 1.1e-28 Identities = 18/42 (42%), Positives = 28/42 (66%) Query: 26 IPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMSRS 67 +PAD + +++ PVV+GR TFES+ LPG +V+SR+ Sbjct: 25 LPADLRHFKAVTLGKPVVMGRRTFESIGRPLPGRRNVVVSRN 66 Score = 92 (41.8 bits), Expect = 1.1e-28, Sum P(3) = 1.1e-28 Identities = 17/45 (37%), Positives = 26/45 (57%) Query: 88 IAASLDAETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 +A D E A +IGG +YA P DR+ L+ + + GDT++P Sbjct: 84 LALLTDCEEAMIIGGGQLYAEALPRADRLYLTYIDAQLNGDTHFP 128 Score = 61 (27.7 bits), Expect = 1.1e-28, Sum P(3) = 1.1e-28 Identities = 10/18 (55%), Positives = 14/18 (77%) Query: 6 VAALAENRVIGRDGELPW 23 +AALA N +IG+D +PW Sbjct: 6 IAALAHNNLIGKDNLIPW 23 Score = 37 (16.8 bits), Expect = 3.5e-14, Sum P(3) = 3.5e-14 Identities = 8/14 (57%), Positives = 10/14 (71%) Query: 84 EAVDIAASLDAETA 97 E V++A SLDA A Sbjct: 72 EGVEVAPSLDAALA 85 sp|P31074|DYRA_ENTAE DIHYDROFOLATE REDUCTASE TYPE I. pir||A39799 dihydrofolate reductase (EC 1.5.1.3) - Enterobacter aerogenes gi|530099 (M26022) dihydrofolate reductase [Enterobacter aerogenes] Length = 159 Score = 101 (45.9 bits), Expect = 9.4e-28, Sum P(3) = 9.4e-28 Identities = 20/45 (44%), Positives = 27/45 (60%) Query: 88 IAASLDAETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 IAA DAE VIGG +Y F P ++ L+ + E EGDT++P Sbjct: 82 IAACGDAEEIMVIGGGRVYEQFLPKAHKLYLTHIDAEVEGDTHFP 126 Score = 82 (37.3 bits), Expect = 9.4e-28, Sum P(3) = 9.4e-28 Identities = 17/40 (42%), Positives = 25/40 (62%) Query: 26 IPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMS 65 +PAD ++ + PVV+GR T+ES+ LPG IV+S Sbjct: 24 LPADLAWFKRNTLNKPVVMGRLTWESIGRPLPGRKNIVIS 63 Score = 57 (25.9 bits), Expect = 9.4e-28, Sum P(3) = 9.4e-28 Identities = 10/18 (55%), Positives = 14/18 (77%) Query: 6 VAALAENRVIGRDGELPW 23 +AALA +RVIG + +PW Sbjct: 5 IAALAVDRVIGMENAMPW 22 pdb|5DFR| Apo-Dihydrofolate Reductase (E.C.1.5.1.3) (DHFR) pdb|6DFR| Dihydrofolate Reductase (E.C.1.5.1.3) (DHFR) Complex With NADP+ pdb|7DFR| Dihydrofolate Reductase (E.C.1.5.1.3) (DHFR) Complex With Folate And NADP+ pdb|3DRC|A Dihydrofolate Reductase (Dhfr) (E.C.1.5.1.3) pdb|3DRC|B Dihydrofolate Reductase (Dhfr) (E.C.1.5.1.3) pdb|1DRH| Dihydrofolate Reductase (5,6,7,8-Tetrahydrofolate: Nadp+ Oxidoreductase, Dhfr) (E.C.1.5.1.3) Complexed With Nadph pdb|1DYH|A Dihydrofolate Reductase (5,6,7,8-Tetrahydrofolate:nadp+ Oxidoreductase, Dhfr) (E.C.1.5.1.3) Complexed With 5-Deazafolate pdb|1DYH|B Dihydrofolate Reductase (5,6,7,8-Tetrahydrofolate:nadp+ Oxidoreductase, Dhfr) (E.C.1.5.1.3) Complexed With 5-Deazafolate pdb|1DYI|A Dihydrofolate Reductase (5,6,7,8-Tetrahydrofolate:nadp+ Oxidoreductase, Dhfr) (E.C.1.5.1.3) Complexed With Folate pdb|1DYI|B Dihydrofolate Reductase (5,6,7,8-Tetrahydrofolate:nadp+ Oxidoreductase, Dhfr) (E.C.1.5.1.3) Complexed With Folate pdb|1DYJ|A Dihydrofolate Reductase (5,6,7,8-Tetrahydrofolate:nadp+ Oxidoreductase, Dhfr) (E.C.1.5.1.3) Complexed With 5,10-Dideazatetrahydrofolate pdb|1DYJ|B Dihydrofolate Reductase (5,6,7,8-Tetrahydrofolate:nadp+ Oxidoreductase, Dhfr) (E.C.1.5.1.3) Complexed With 5,10-Dideazatetrahydrofolate Length = 159 Score = 92 (41.8 bits), Expect = 4.4e-27, Sum P(3) = 4.4e-27 Identities = 18/45 (40%), Positives = 25/45 (55%) Query: 88 IAASLDAETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 IAA D VIGG +Y F P ++ L+ + E EGDT++P Sbjct: 82 IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126 Score = 86 (39.1 bits), Expect = 4.4e-27, Sum P(3) = 4.4e-27 Identities = 16/41 (39%), Positives = 26/41 (63%) Query: 25 SIPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMS 65 ++PAD ++ D PV++GR T+ES+ LPG I++S Sbjct: 23 NLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILS 63 Score = 57 (25.9 bits), Expect = 4.4e-27, Sum P(3) = 4.4e-27 Identities = 10/18 (55%), Positives = 14/18 (77%) Query: 6 VAALAENRVIGRDGELPW 23 +AALA +RVIG + +PW Sbjct: 5 IAALAVDRVIGMENAMPW 22 pdb|4DFR|A Dihydrofolate Reductase (E.C.1.5.1.3) Complex With Methotrexate pdb|4DFR|B Dihydrofolate Reductase (E.C.1.5.1.3) Complex With Methotrexate pdb|1TDR|A Molecule: Telluromethionyl Dihydrofolate Reductase; Synonyms: Dhfr; Ec: 1.5.1.3; Heterogen: Methotrexate; Heterogen: Cacl2 pdb|1TDR|B Molecule: Telluromethionyl Dihydrofolate Reductase; Synonyms: Dhfr; Ec: 1.5.1.3; Heterogen: Methotrexate; Heterogen: Cacl2 Length = 159 Score = 92 (41.8 bits), Expect = 4.4e-27, Sum P(3) = 4.4e-27 Identities = 18/45 (40%), Positives = 25/45 (55%) Query: 88 IAASLDAETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 IAA D VIGG +Y F P ++ L+ + E EGDT++P Sbjct: 82 IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126 Score = 86 (39.1 bits), Expect = 4.4e-27, Sum P(3) = 4.4e-27 Identities = 16/41 (39%), Positives = 26/41 (63%) Query: 25 SIPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMS 65 ++PAD ++ D PV++GR T+ES+ LPG I++S Sbjct: 23 NLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILS 63 Score = 57 (25.9 bits), Expect = 4.4e-27, Sum P(3) = 4.4e-27 Identities = 10/18 (55%), Positives = 14/18 (77%) Query: 6 VAALAENRVIGRDGELPW 23 +AALA +RVIG + +PW Sbjct: 5 IAALAVDRVIGMENAMPW 22 pdb|1DRA|A Dihydrofolate Reductase (Dhfr) (E.C.1.5.1.3) Mutant With Asp 27 Replaced By Glu (D27e) pdb|1DRA|B Dihydrofolate Reductase (Dhfr) (E.C.1.5.1.3) Mutant With Asp 27 Replaced By Glu (D27e) Length = 159 Score = 92 (41.8 bits), Expect = 1.5e-26, Sum P(3) = 1.5e-26 Identities = 18/45 (40%), Positives = 25/45 (55%) Query: 88 IAASLDAETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 IAA D VIGG +Y F P ++ L+ + E EGDT++P Sbjct: 82 IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126 Score = 82 (37.3 bits), Expect = 1.5e-26, Sum P(3) = 1.5e-26 Identities = 15/41 (36%), Positives = 26/41 (63%) Query: 25 SIPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMS 65 ++PA+ ++ D PV++GR T+ES+ LPG I++S Sbjct: 23 NLPAELAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILS 63 Score = 57 (25.9 bits), Expect = 1.5e-26, Sum P(3) = 1.5e-26 Identities = 10/18 (55%), Positives = 14/18 (77%) Query: 6 VAALAENRVIGRDGELPW 23 +AALA +RVIG + +PW Sbjct: 5 IAALAVDRVIGMENAMPW 22 sp|P00379|DYRA_ECOLI DIHYDROFOLATE REDUCTASE TYPE I. pir||RDECD dihydrofolate reductase (EC 1.5.1.3) type I - Escherichia coli gi|146006 (J01609) dihydrofolate reductase [Escherichia coli] gi|216473 (D10483) dehydrofolate reductase, type I [Escherichia coli] Length = 159 Score = 92 (41.8 bits), Expect = 2.0e-26, Sum P(3) = 2.0e-26 Identities = 18/45 (40%), Positives = 25/45 (55%) Query: 88 IAASLDAETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 IAA D VIGG +Y F P ++ L+ + E EGDT++P Sbjct: 82 IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126 Score = 81 (36.8 bits), Expect = 2.0e-26, Sum P(3) = 2.0e-26 Identities = 15/41 (36%), Positives = 26/41 (63%) Query: 25 SIPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMS 65 ++PAD ++ + PV++GR T+ES+ LPG I++S Sbjct: 23 NLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 63 Score = 57 (25.9 bits), Expect = 2.0e-26, Sum P(3) = 2.0e-26 Identities = 10/18 (55%), Positives = 14/18 (77%) Query: 6 VAALAENRVIGRDGELPW 23 +AALA +RVIG + +PW Sbjct: 5 IAALAVDRVIGMENAMPW 22 gi|41265 (X05108) dihydrofolate reductase (AA 1-159) [Escherichia coli] Length = 159 Score = 92 (41.8 bits), Expect = 2.0e-26, Sum P(3) = 2.0e-26 Identities = 18/45 (40%), Positives = 25/45 (55%) Query: 88 IAASLDAETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 IAA D VIGG +Y F P ++ L+ + E EGDT++P Sbjct: 82 IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126 Score = 81 (36.8 bits), Expect = 2.0e-26, Sum P(3) = 2.0e-26 Identities = 15/41 (36%), Positives = 26/41 (63%) Query: 25 SIPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMS 65 ++PAD ++ + PV++GR T+ES+ LPG I++S Sbjct: 23 NLPADLAGFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 63 Score = 57 (25.9 bits), Expect = 2.0e-26, Sum P(3) = 2.0e-26 Identities = 10/18 (55%), Positives = 14/18 (77%) Query: 6 VAALAENRVIGRDGELPW 23 +AALA +RVIG + +PW Sbjct: 5 IAALAVDRVIGMENAMPW 22 sp|P31073|DYRA_CITFR DIHYDROFOLATE REDUCTASE TYPE I. pir||B39799 dihydrofolate reductase (EC 1.5.1.3) - Citrobacter freundii gi|530096 (M26023) dihydrofolate reductase [Citrobacter freundii] Length = 159 Score = 91 (41.4 bits), Expect = 2.0e-26, Sum P(3) = 2.0e-26 Identities = 18/45 (40%), Positives = 25/45 (55%) Query: 88 IAASLDAETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 IAA D VIGG +Y F P ++ L+ + E EGDT++P Sbjct: 82 IAACGDEPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126 Score = 82 (37.3 bits), Expect = 2.0e-26, Sum P(3) = 2.0e-26 Identities = 17/41 (41%), Positives = 26/41 (63%) Query: 25 SIPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMS 65 ++PAD ++ + PVV+GR T+ES+ LPG IV+S Sbjct: 23 NLPADLAWFKRNTLNKPVVMGRHTWESIGRPLPGRKNIVIS 63 Score = 57 (25.9 bits), Expect = 2.0e-26, Sum P(3) = 2.0e-26 Identities = 10/18 (55%), Positives = 14/18 (77%) Query: 6 VAALAENRVIGRDGELPW 23 +AALA +RVIG + +PW Sbjct: 5 IAALAVDRVIGMENAMPW 22 pdb|1DHI|A Dihydrofolate Reductase (Dhfr) (E.C.1.5.1.3) Mutant With Asp 27 Replaced By Ser (D27s) Complexed With Methotrexate pdb|1DHI|B Dihydrofolate Reductase (Dhfr) (E.C.1.5.1.3) Mutant With Asp 27 Replaced By Ser (D27s) Complexed With Methotrexate Length = 159 Score = 92 (41.8 bits), Expect = 2.8e-26, Sum P(3) = 2.8e-26 Identities = 18/45 (40%), Positives = 25/45 (55%) Query: 88 IAASLDAETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 IAA D VIGG +Y F P ++ L+ + E EGDT++P Sbjct: 82 IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126 Score = 80 (36.4 bits), Expect = 2.8e-26, Sum P(3) = 2.8e-26 Identities = 15/41 (36%), Positives = 25/41 (60%) Query: 25 SIPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMS 65 ++PA ++ D PV++GR T+ES+ LPG I++S Sbjct: 23 NLPASLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILS 63 Score = 57 (25.9 bits), Expect = 2.8e-26, Sum P(3) = 2.8e-26 Identities = 10/18 (55%), Positives = 14/18 (77%) Query: 6 VAALAENRVIGRDGELPW 23 +AALA +RVIG + +PW Sbjct: 5 IAALAVDRVIGMENAMPW 22 pdb|1DHJ|A Dihydrofolate Reductase (Dhfr) (E.C.1.5.1.3) Mutant With Asp 27 Replaced By Ser And Phe 137 Replaced By Ser (D27s,F137s) Complexed With Methotrexate pdb|1DHJ|B Dihydrofolate Reductase (Dhfr) (E.C.1.5.1.3) Mutant With Asp 27 Replaced By Ser And Phe 137 Replaced By Ser (D27s,F137s) Complexed With Methotrexate Length = 159 Score = 92 (41.8 bits), Expect = 2.8e-26, Sum P(3) = 2.8e-26 Identities = 18/45 (40%), Positives = 25/45 (55%) Query: 88 IAASLDAETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 IAA D VIGG +Y F P ++ L+ + E EGDT++P Sbjct: 82 IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126 Score = 80 (36.4 bits), Expect = 2.8e-26, Sum P(3) = 2.8e-26 Identities = 15/41 (36%), Positives = 25/41 (60%) Query: 25 SIPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMS 65 ++PA ++ D PV++GR T+ES+ LPG I++S Sbjct: 23 NLPASLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILS 63 Score = 57 (25.9 bits), Expect = 2.8e-26, Sum P(3) = 2.8e-26 Identities = 10/18 (55%), Positives = 14/18 (77%) Query: 6 VAALAENRVIGRDGELPW 23 +AALA +RVIG + +PW Sbjct: 5 IAALAVDRVIGMENAMPW 22 pdb|1DRB|A Dihydrofolate Reductase (Dhfr) (E.C.1.5.1.3) Mutant With Asp 27 Replaced By Cys (D27c) pdb|1DRB|B Dihydrofolate Reductase (Dhfr) (E.C.1.5.1.3) Mutant With Asp 27 Replaced By Cys (D27c) Length = 159 Score = 92 (41.8 bits), Expect = 6.9e-26, Sum P(3) = 6.9e-26 Identities = 18/45 (40%), Positives = 25/45 (55%) Query: 88 IAASLDAETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 IAA D VIGG +Y F P ++ L+ + E EGDT++P Sbjct: 82 IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126 Score = 77 (35.0 bits), Expect = 6.9e-26, Sum P(3) = 6.9e-26 Identities = 15/41 (36%), Positives = 25/41 (60%) Query: 25 SIPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMS 65 ++PA ++ D PV++GR T+ES+ LPG I++S Sbjct: 23 NLPACLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILS 63 Score = 57 (25.9 bits), Expect = 6.9e-26, Sum P(3) = 6.9e-26 Identities = 10/18 (55%), Positives = 14/18 (77%) Query: 6 VAALAENRVIGRDGELPW 23 +AALA +RVIG + +PW Sbjct: 5 IAALAVDRVIGMENAMPW 22 pdb|2DRC|A Dihydrofolate Reductase (Dhfr) (E.C.1.5.1.3) Mutant With Trp 22 Replaced By Phe (W22f) pdb|2DRC|B Dihydrofolate Reductase (Dhfr) (E.C.1.5.1.3) Mutant With Trp 22 Replaced By Phe (W22f) Length = 159 Score = 92 (41.8 bits), Expect = 9.4e-26, Sum P(3) = 9.4e-26 Identities = 18/45 (40%), Positives = 25/45 (55%) Query: 88 IAASLDAETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 IAA D VIGG +Y F P ++ L+ + E EGDT++P Sbjct: 82 IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 126 Score = 86 (39.1 bits), Expect = 9.4e-26, Sum P(3) = 9.4e-26 Identities = 16/41 (39%), Positives = 26/41 (63%) Query: 25 SIPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMS 65 ++PAD ++ D PV++GR T+ES+ LPG I++S Sbjct: 23 NLPADLAWFKRNTLDKPVIMGRHTWESIGRPLPGRKNIILS 63 Score = 47 (21.4 bits), Expect = 9.4e-26, Sum P(3) = 9.4e-26 Identities = 9/18 (50%), Positives = 14/18 (77%) Query: 6 VAALAENRVIGRDGELPW 23 +AALA +RVIG + +P+ Sbjct: 5 IAALAVDRVIGMENAMPF 22 sp|P43791|DYRA_HAEIN DIHYDROFOLATE REDUCTASE TYPE I. pir||C64101 dehydrofolate reductase, type I (folA) homolog - Haemophilus influenzae (strain Rd KW20) gi|1205146 (U00078) dehydrofolate reductase, type I [Haemophilus influenzae] gi|1221004 (U32718) dihydrofolate reductase [Haemophilus influenzae] Length = 160 Score = 88 (40.0 bits), Expect = 1.9e-23, Sum P(3) = 1.9e-23 Identities = 18/41 (43%), Positives = 24/41 (58%) Query: 26 IPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMSR 66 +PAD +R PV++GR TFES+ LP IV+SR Sbjct: 25 LPADLAWFRQNTTGKPVIMGRKTFESIGRPLPKRTNIVLSR 65 Score = 78 (35.5 bits), Expect = 1.9e-23, Sum P(3) = 1.9e-23 Identities = 12/40 (30%), Positives = 25/40 (62%) Query: 93 DAETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 D + +IGG ++ + P D++ L+++ E +GDT++P Sbjct: 88 DFDEIMLIGGGELFKQYLPKADKLYLTQIQTELDGDTFFP 127 Score = 53 (24.1 bits), Expect = 1.9e-23, Sum P(3) = 1.9e-23 Identities = 8/18 (44%), Positives = 12/18 (66%) Query: 6 VAALAENRVIGRDGELPW 23 + A N VIG+D ++PW Sbjct: 6 IVATTLNNVIGKDNQMPW 23 pir||S52336 dihydrofolate reductase (EC 1.5.1.3) - Haemophilus influenzae gi|665643 (X84207) dihydrofolate reductase [Haemophilus influenzae] Length = 160 Score = 88 (40.0 bits), Expect = 4.5e-23, Sum P(3) = 4.5e-23 Identities = 18/41 (43%), Positives = 24/41 (58%) Query: 26 IPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMSR 66 +PAD +R PV++GR TFES+ LP IV+SR Sbjct: 25 LPADLAWFRQNTTGKPVIMGRKTFESIGRPLPKRTNIVLSR 65 Score = 78 (35.5 bits), Expect = 4.5e-23, Sum P(3) = 4.5e-23 Identities = 12/40 (30%), Positives = 25/40 (62%) Query: 93 DAETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 D + +IGG ++ + P D++ L+++ E +GDT++P Sbjct: 88 DFDEIMLIGGGELFKQYLPKADKLYLTQIQTELDGDTFFP 127 Score = 52 (23.6 bits), Expect = 4.5e-23, Sum P(3) = 4.5e-23 Identities = 8/18 (44%), Positives = 12/18 (66%) Query: 6 VAALAENRVIGRDGELPW 23 + A N VIG+D ++PW Sbjct: 6 IVATTLNSVIGKDNQMPW 23 Score = 37 (16.8 bits), Expect = 3.8, Sum P(2) = 0.98 Identities = 8/17 (47%), Positives = 11/17 (64%) Query: 111 PHLDRMVLSRVPGEYEG 127 P +VLSR P ++EG Sbjct: 56 PKRTNIVLSRQPFKHEG 72 sp|P27498|DYRA_KLEAE DIHYDROFOLATE REDUCTASE TYPE I. pir||RDKBD dihydrofolate reductase (EC 1.5.1.3) - Klebsiella pneumoniae gi|216719 (D10358) dihydrofolate reductase [Klebsiella aerogenes] Length = 159 Score = 96 (43.6 bits), Expect = 4.9e-23, Sum P(3) = 4.9e-23 Identities = 19/45 (42%), Positives = 26/45 (57%) Query: 88 IAASLDAETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 IAA D E VIGG +Y F P ++ L+ + E EGDT++P Sbjct: 82 IAACGDVEEIMVIGGGRVYDEFLPKAQKLYLTHIDAEVEGDTHFP 126 Score = 69 (31.4 bits), Expect = 4.9e-23, Sum P(3) = 4.9e-23 Identities = 15/37 (40%), Positives = 22/37 (59%) Query: 29 DKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMS 65 D ++ + PVV+GR T+ES+ LPG IV+S Sbjct: 27 DLAWFKRNTLNKPVVMGRLTWESIGRPLPGRKNIVIS 63 Score = 52 (23.6 bits), Expect = 4.9e-23, Sum P(3) = 4.9e-23 Identities = 9/18 (50%), Positives = 13/18 (72%) Query: 6 VAALAENRVIGRDGELPW 23 +AAL +RVIG + +PW Sbjct: 5 IAALRVDRVIGMENAMPW 22 gi|950044 (Z50802) dihydrofolate reductase [Escherichia coli] Length = 165 Score = 84 (38.2 bits), Expect = 2.7e-22, Sum P(3) = 2.7e-22 Identities = 16/35 (45%), Positives = 22/35 (62%) Query: 98 YVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 YV GA +YAL PH + + LS V +EGD ++P Sbjct: 100 YVARGAEVYALALPHANGVFLSEVHQTFEGDAFFP 134 Score = 78 (35.5 bits), Expect = 2.7e-22, Sum P(3) = 2.7e-22 Identities = 17/41 (41%), Positives = 24/41 (58%) Query: 26 IPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMSR 66 IP ++K +R VV+GR TFES+ LP +V+SR Sbjct: 30 IPGEQKIFRRLTESKVVVMGRKTFESIGKPLPNRHTVVLSR 70 Score = 57 (25.9 bits), Expect = 2.7e-22, Sum P(3) = 2.7e-22 Identities = 10/18 (55%), Positives = 13/18 (72%) Query: 6 VAALAENRVIGRDGELPW 23 VAA+ NRVIG ++PW Sbjct: 11 VAAMGANRVIGNGPDIPW 28 pir||S52337 dihydrofolate reductase (EC 1.5.1.3) - Haemophilus influenzae gi|665645 (X84205) dihydrofolate reductase [Haemophilus influenzae] Length = 160 Score = 87 (39.6 bits), Expect = 3.9e-22, Sum P(3) = 3.9e-22 Identities = 18/41 (43%), Positives = 24/41 (58%) Query: 26 IPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMSR 66 +PAD +R PV++GR TFES+ LP IV+SR Sbjct: 25 LPADLAWFRQNTTGKPVIMGRKTFESIGRALPKRTNIVLSR 65 Score = 76 (34.6 bits), Expect = 3.9e-22, Sum P(3) = 3.9e-22 Identities = 11/40 (27%), Positives = 25/40 (62%) Query: 93 DAETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 D + ++GG ++ + P D++ L+++ E +GDT++P Sbjct: 88 DFDEIMLLGGGELFKQYLPKADKLYLTQIQTELDGDTFFP 127 Score = 52 (23.6 bits), Expect = 3.9e-22, Sum P(3) = 3.9e-22 Identities = 8/18 (44%), Positives = 12/18 (66%) Query: 6 VAALAENRVIGRDGELPW 23 + A N VIG+D ++PW Sbjct: 6 IVATTLNSVIGKDNQIPW 23 pir||A48898 dihydrofolate reductase (EC 1.5.1.3) type XII - Escherichia coli plasmid gi|49351 (Z21672) dihydrofolate reductase [Escherichia coli] gi|145738 (M84522) dihydrofolate reductase [Escherichia coli] Length = 165 Score = 87 (39.6 bits), Expect = 7.9e-22, Sum P(3) = 7.9e-22 Identities = 17/35 (48%), Positives = 21/35 (60%) Query: 98 YVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 YV GGA IY L PH + LS V +EGD ++P Sbjct: 100 YVAGGAEIYTLALPHAHGVFLSEVHQTFEGDAFFP 134 Score = 75 (34.1 bits), Expect = 7.9e-22, Sum P(3) = 7.9e-22 Identities = 17/41 (41%), Positives = 24/41 (58%) Query: 26 IPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMSR 66 IP ++K +R VV+GR TFES+ LP +V+SR Sbjct: 30 IPGEQKIFRRLTEGKVVVMGRKTFESIGKPLPNRHTLVISR 70 Score = 55 (25.0 bits), Expect = 7.9e-22, Sum P(3) = 7.9e-22 Identities = 10/18 (55%), Positives = 12/18 (66%) Query: 6 VAALAENRVIGRDGELPW 23 VAA+ NRVIG +PW Sbjct: 11 VAAMGANRVIGNGPNIPW 28 pir||S52338 dihydrofolate reductase (EC 1.5.1.3) - Haemophilus influenzae gi|665647 (X84206) dihydrofolate reductase [Haemophilus influenzae] Length = 160 Score = 80 (36.4 bits), Expect = 4.0e-21, Sum P(3) = 4.0e-21 Identities = 17/41 (41%), Positives = 23/41 (56%) Query: 26 IPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMSR 66 +PAD +R PV++GR TFES+ L IV+SR Sbjct: 25 LPADLAWFRQNTTGKPVIMGRKTFESIGRPLAKRTNIVLSR 65 Score = 78 (35.5 bits), Expect = 4.0e-21, Sum P(3) = 4.0e-21 Identities = 12/40 (30%), Positives = 25/40 (62%) Query: 93 DAETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 D + +IGG ++ + P D++ L+++ E +GDT++P Sbjct: 88 DFDEIMLIGGGELFKQYLPKADKLYLTQIQTELDGDTFFP 127 Score = 53 (24.1 bits), Expect = 4.0e-21, Sum P(3) = 4.0e-21 Identities = 8/18 (44%), Positives = 12/18 (66%) Query: 6 VAALAENRVIGRDGELPW 23 + A N VIG+D ++PW Sbjct: 6 IVATTLNNVIGKDNQMPW 23 gi|971590 (Z50141) dihydrofolate reductase [Staphylococcus haemolyticus] gi|1150987 (U43152) dihydrofolate reductase DHFR L1 protein [Listeria monocytogenes] gi|1244657 (U40997) dihydrofolate reductase [Listeria monocytogenes] Length = 162 Score = 101 (45.9 bits), Expect = 1.2e-20, Sum P(3) = 1.2e-20 Identities = 14/38 (36%), Positives = 28/38 (73%) Query: 95 ETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 E ++ GG IY +F P++++M ++++ E+EGDT++P Sbjct: 91 EEVFIFGGEQIYVMFLPYVEKMYVTKIHHEFEGDTFFP 128 Score = 61 (27.7 bits), Expect = 1.2e-20, Sum P(3) = 1.2e-20 Identities = 9/23 (39%), Positives = 17/23 (73%) Query: 1 MELVSVAALAENRVIGRDGELPW 23 M++ + A+ + RVIG+D ++PW Sbjct: 1 MKISLIVAMDKKRVIGKDNDIPW 23 Score = 48 (21.8 bits), Expect = 1.2e-20, Sum P(3) = 1.2e-20 Identities = 10/43 (23%), Positives = 22/43 (51%) Query: 26 IPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMSRSE 68 I +D + ++ ++LGR +S+ LP I+++R + Sbjct: 25 ISSDWEYVKNTTKGHAIILGRKNLQSIGRALPDRRNIILTRDK 67 sp|P11045|DYR_BACSU DIHYDROFOLATE REDUCTASE. pir||RDBSD dihydrofolate reductase (EC 1.5.1.3) - Bacillus subtilis gi|143742 (M20012) dihydrofolate reductase (dfrA) [Bacillus subtilis] Length = 168 Score = 92 (41.8 bits), Expect = 1.6e-20, Sum P(3) = 1.6e-20 Identities = 15/38 (39%), Positives = 26/38 (68%) Query: 95 ETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 E +VIGGA +Y P+ DR+ ++++ E+EGD ++P Sbjct: 90 EECFVIGGAQLYTDLFPYADRLYMTKIHHEFEGDRHFP 127 Score = 62 (28.2 bits), Expect = 1.6e-20, Sum P(3) = 1.6e-20 Identities = 13/45 (28%), Positives = 24/45 (53%) Query: 26 IPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMSRSERS 70 +P D ++ + +++GR TFES+ LP IV++ + S Sbjct: 24 LPNDLAYFKKITSGHSIIMGRKTFESIGRPLPNRKNIVVTSAPDS 68 Score = 58 (26.4 bits), Expect = 1.6e-20, Sum P(3) = 1.6e-20 Identities = 9/18 (50%), Positives = 14/18 (77%) Query: 6 VAALAENRVIGRDGELPW 23 + A+ NR+IG+D +LPW Sbjct: 5 IFAMDANRLIGKDNDLPW 22 gi|1256641 (L77246) dihydrofolate reductase [Bacillus subtilis] Length = 168 Score = 92 (41.8 bits), Expect = 1.6e-20, Sum P(3) = 1.6e-20 Identities = 15/38 (39%), Positives = 26/38 (68%) Query: 95 ETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 E +VIGGA +Y P+ DR+ ++++ E+EGD ++P Sbjct: 90 EECFVIGGAQLYTDLFPYADRLYMTKIHHEFEGDRHFP 127 Score = 62 (28.2 bits), Expect = 1.6e-20, Sum P(3) = 1.6e-20 Identities = 13/45 (28%), Positives = 24/45 (53%) Query: 26 IPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMSRSERS 70 +P D ++ + +++GR TFES+ LP IV++ + S Sbjct: 24 LPNDLAYFKKITSGHSIIMGRKTFESIGRPLPNRKNIVVTSAPDS 68 Score = 58 (26.4 bits), Expect = 1.6e-20, Sum P(3) = 1.6e-20 Identities = 9/18 (50%), Positives = 14/18 (77%) Query: 6 VAALAENRVIGRDGELPW 23 + A+ NR+IG+D +LPW Sbjct: 5 IFAMDANRLIGKDNDLPW 22 pir||S47467 dihydrofolate reductase (EC 1.5.1.3) - Lactococcus lactis gi|530024 (X60681) dihydrofolate reductase [Lactococcus lactis] Length = 168 Score = 79 (35.9 bits), Expect = 1.1e-19, Sum P(4) = 1.1e-19 Identities = 14/35 (40%), Positives = 24/35 (68%) Query: 98 YVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 ++ GGA I ALF+ L+ + + V +++GDTY+P Sbjct: 97 FITGGAEILALFESELELLYRTVVHEKFQGDTYFP 131 Score = 63 (28.6 bits), Expect = 1.1e-19, Sum P(4) = 1.1e-19 Identities = 10/28 (35%), Positives = 19/28 (67%) Query: 25 SIPADKKQYRSRIADDPVVLGRTTFESM 52 S+PA++K ++ + +++GR TFE M Sbjct: 23 SLPAEQKHFKETTMNQVILMGRKTFEGM 50 Score = 36 (16.4 bits), Expect = 1.1e-19, Sum P(4) = 1.1e-19 Identities = 6/21 (28%), Positives = 12/21 (57%) Query: 3 LVSVAALAENRVIGRDGELPW 23 ++ + A E +IG ++PW Sbjct: 2 IIGIWAEDEQGLIGEADKMPW 22 Score = 35 (15.9 bits), Expect = 1.1e-19, Sum P(4) = 1.1e-19 Identities = 6/13 (46%), Positives = 9/13 (69%) Query: 56 LPGSAQIVMSRSE 68 LPG I+++R E Sbjct: 55 LPGRISIILTRDE 67 gi|971589 (Z50141) dihydrofolate reductase [Staphylococcus haemolyticus] Length = 166 Score = 101 (45.9 bits), Expect = 4.9e-19, Sum P(3) = 4.9e-19 Identities = 14/38 (36%), Positives = 28/38 (73%) Query: 95 ETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 E ++ GG IY +F P++++M ++++ E+EGDT++P Sbjct: 95 EEVFIFGGEQIYVMFLPYVEKMYVTKIHHEFEGDTFFP 132 Score = 58 (26.4 bits), Expect = 4.9e-19, Sum P(3) = 4.9e-19 Identities = 8/23 (34%), Positives = 17/23 (73%) Query: 1 MELVSVAALAENRVIGRDGELPW 23 +++ + A+ + RVIG+D ++PW Sbjct: 5 LKISLIVAMDKKRVIGKDNDIPW 27 Score = 48 (21.8 bits), Expect = 4.9e-19, Sum P(3) = 4.9e-19 Identities = 10/43 (23%), Positives = 22/43 (51%) Query: 26 IPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMSRSE 68 I +D + ++ ++LGR +S+ LP I+++R + Sbjct: 29 ISSDWEYVKNTTKGHAIILGRKNLQSIGRALPDRRNIILTRDK 71 gi|469211 (D28814) The fusion protein, composed of hepatitis C virus (HCV) p21(nonstructural protein NS2),E.coli dihydroforate reductase, substrate polypptide for HCV serine proteinase and TAX of HTLV-I [Hepatitis C virus] Length = 847 Score = 92 (41.8 bits), Expect = 6.9e-19, Sum P(3) = 6.9e-19 Identities = 18/45 (40%), Positives = 25/45 (55%) Query: 88 IAASLDAETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 IAA D VIGG +Y F P ++ L+ + E EGDT++P Sbjct: 385 IAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVEGDTHFP 429 Score = 81 (36.8 bits), Expect = 6.9e-19, Sum P(3) = 6.9e-19 Identities = 15/41 (36%), Positives = 26/41 (63%) Query: 25 SIPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMS 65 ++PAD ++ + PV++GR T+ES+ LPG I++S Sbjct: 326 NLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNIILS 366 Score = 57 (25.9 bits), Expect = 6.9e-19, Sum P(3) = 6.9e-19 Identities = 10/18 (55%), Positives = 14/18 (77%) Query: 6 VAALAENRVIGRDGELPW 23 +AALA +RVIG + +PW Sbjct: 308 IAALAVDRVIGMENAMPW 325 pir||S57629 dihydrofolate reductase (EC 1.5.1.3) - Staphylococcus epidermidis gi|886710 (Z48233) dihydrofolate reductase [Staphylococcus epidermidis] Length = 161 Score = 69 (31.4 bits), Expect = 2.2e-18, Sum P(4) = 2.2e-18 Identities = 9/35 (25%), Positives = 22/35 (62%) Query: 98 YVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 ++ GG ++ +D M ++ + G+++GDT++P Sbjct: 91 FIFGGQTLFEAMIDQVDDMYITVIDGKFQGDTFFP 125 Score = 61 (27.7 bits), Expect = 2.2e-18, Sum P(4) = 2.2e-18 Identities = 12/40 (30%), Positives = 21/40 (52%) Query: 26 IPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMS 65 +P D K + + +V+GR TF S+ LP +V++ Sbjct: 25 LPNDLKHVKQLTTGNTLVMGRKTFNSIGKPLPNRRNVVLT 64 Score = 48 (21.8 bits), Expect = 2.2e-18, Sum P(4) = 2.2e-18 Identities = 10/23 (43%), Positives = 13/23 (56%) Query: 1 MELVSVAALAENRVIGRDGELPW 23 M L + A + RVIG +LPW Sbjct: 1 MTLSIIVAHDKQRVIGYQNQLPW 23 Score = 32 (14.5 bits), Expect = 2.2e-18, Sum P(4) = 2.2e-18 Identities = 8/22 (36%), Positives = 13/22 (59%) Query: 72 SVDTAHRAASVEEAVDIAASLD 93 +V ++A+ E VD+ SLD Sbjct: 60 NVVLTNQASFHHEGVDVINSLD 81 gnl|PID|e252738 (Z74778) dihydrofolate reductase (DHFR) [Streptococcus pneumoniae] Length = 168 Score = 101 (45.9 bits), Expect = 1.2e-16, Sum P(3) = 1.2e-16 Identities = 15/35 (42%), Positives = 25/35 (71%) Query: 98 YVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 Y+IGG I+ F+P+LD ++++ + EGDTY+P Sbjct: 98 YIIGGKQIFQAFEPYLDEVIVTHIHARVEGDTYFP 132 Score = 51 (23.2 bits), Expect = 1.2e-16, Sum P(3) = 1.2e-16 Identities = 9/22 (40%), Positives = 15/22 (68%) Query: 2 ELVSVAALAENRVIGRDGELPW 23 ++V++ A E VIG++ LPW Sbjct: 4 KIVAIWAQDEEGVIGKENRLPW 25 Score = 50 (22.7 bits), Expect = 1.2e-16, Sum P(3) = 1.2e-16 Identities = 7/27 (25%), Positives = 17/27 (62%) Query: 26 IPADKKQYRSRIADDPVVLGRTTFESM 52 +PA+ + ++ + +++GR TF+ M Sbjct: 27 LPAELQHFKETTLNHAILMGRVTFDGM 53 gi|507215 (U10186) dihydrofolate reductase type VIII [Escherichia coli] gi|516010 (U09273) dihydrofolate reductase [Shigella sonnei] Length = 169 Score = 118 (53.6 bits), Expect = 2.6e-16, Sum P(2) = 2.6e-16 Identities = 24/66 (36%), Positives = 37/66 (56%) Query: 1 MELVSVAALAENRVIGRDGELPWPSIPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSA 60 +EL ++ A N IG+D LPWP + D +++ V++GR T+ES+ L G Sbjct: 2 IELHAILAATANGCIGKDNALPWPPLKGDLARFKKLTMGKVVIMGRKTYESLPVKLEGRT 61 Query: 61 QIVMSR 66 IVM+R Sbjct: 62 CIVMTR 67 Score = 71 (32.3 bits), Expect = 2.6e-16, Sum P(2) = 2.6e-16 Identities = 16/36 (44%), Positives = 22/36 (61%) Query: 95 ETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTY 130 + AYVIGGA I+ + ++ L+ V YEGDTY Sbjct: 101 DVAYVIGGAEIFKRLALMITQIELTFVKRLYEGDTY 136 gnl|PID|e252737 (Z74777) trimethoprim resistant dihydrofolate reductase (DHFR) [Streptococcus pneumoniae] Length = 168 Score = 91 (41.4 bits), Expect = 6.7e-15, Sum P(3) = 6.7e-15 Identities = 13/35 (37%), Positives = 24/35 (68%) Query: 98 YVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 Y++GG I+ F+ +LD ++++ + EGDTY+P Sbjct: 98 YILGGKQIFQAFESYLDEVIVTHIHARVEGDTYFP 132 Score = 55 (25.0 bits), Expect = 6.7e-15, Sum P(3) = 6.7e-15 Identities = 10/22 (45%), Positives = 15/22 (68%) Query: 2 ELVSVAALAENRVIGRDGELPW 23 ++V++ A E VIG+D LPW Sbjct: 4 KIVAIWAQDEEGVIGKDNRLPW 25 Score = 50 (22.7 bits), Expect = 6.7e-15, Sum P(3) = 6.7e-15 Identities = 7/27 (25%), Positives = 17/27 (62%) Query: 26 IPADKKQYRSRIADDPVVLGRTTFESM 52 +PA+ + ++ + +++GR TF+ M Sbjct: 27 LPAELQHFKETTLNHAILMGRVTFDGM 53 sp|P04174|DYR_NEIGO DIHYDROFOLATE REDUCTASE. pir||RDNHD dihydrofolate reductase (EC 1.5.1.3) - Neisseria gonorrhoeae Length = 162 Score = 71 (32.3 bits), Expect = 2.2e-11, Sum P(3) = 2.2e-11 Identities = 16/47 (34%), Positives = 24/47 (51%) Query: 86 VDIAASLDAETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 V +A AE A ++GGA IY P + ++ V EGD ++P Sbjct: 84 VALALCAGAEEAVIMGGAQIYGQAMPLATDLRITEVDLSVEGDAFFP 130 Score = 56 (25.5 bits), Expect = 2.2e-11, Sum P(3) = 2.2e-11 Identities = 16/68 (23%), Positives = 31/68 (45%) Query: 26 IPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMSRSERSFSVDTAHRAASVEEA 85 IP D ++ PV++GR T+ES+ + ++ + + A AS+E A Sbjct: 26 IPEDFAFFKVYTLGKPVIMGRKTWESLPVKPLPGRRNIVISRQADYCAAGAETVASLEVA 85 Query: 86 VDIAASLD 93 + + A + Sbjct: 86 LALCAGAE 93 Score = 52 (23.6 bits), Expect = 2.2e-11, Sum P(3) = 2.2e-11 Identities = 9/23 (39%), Positives = 14/23 (60%) Query: 1 MELVSVAALAENRVIGRDGELPW 23 +++ +AA AEN IG +PW Sbjct: 2 LKITIIAACAENLCIGAGNAMPW 24 gi|950039 (Z50805) dihydrofolate reductase type Ib [Escherichia coli] Length = 157 Score = 55 (25.0 bits), Expect = 9.5e-11, Sum P(4) = 9.5e-11 Identities = 13/34 (38%), Positives = 17/34 (50%) Query: 99 VIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 V GG IY P + LS + E EGD ++P Sbjct: 96 VSGGGEIYRETLPMASTLHLSTIDIEPEGDVFFP 129 Score = 51 (23.2 bits), Expect = 9.5e-11, Sum P(4) = 9.5e-11 Identities = 10/23 (43%), Positives = 16/23 (69%) Query: 1 MELVSVAALAENRVIGRDGELPW 23 M++ +AA A+N VIG ++PW Sbjct: 1 MKVSLIAAKAKNGVIGCGPDIPW 23 Score = 42 (19.1 bits), Expect = 9.5e-11, Sum P(4) = 9.5e-11 Identities = 14/47 (29%), Positives = 20/47 (42%) Query: 56 LPGSAQIVMSRSERSFSVDTAHRAASVEEAVDIAASLDAETAYVIGG 102 LP V++RS + + D S+EEA+D A GG Sbjct: 54 LPNRKYAVVTRSGWTSNDDNVVVFQSIEEAMDRLAEFTGHVIVSGGG 100 Score = 38 (17.3 bits), Expect = 9.5e-11, Sum P(4) = 9.5e-11 Identities = 7/11 (63%), Positives = 10/11 (90%) Query: 42 VVLGRTTFESM 52 +++GR TFESM Sbjct: 41 LLVGRKTFESM 51 pdb|3DFR| Dihydrofolate Reductase (E.C.1.5.1.3) Complex With Nadph And Methotrexate Length = 162 Score = 75 (34.1 bits), Expect = 4.8e-10, Sum P(3) = 4.8e-10 Identities = 12/31 (38%), Positives = 22/31 (70%) Query: 99 VIGGAAIYALFQPHLDRMVLSRVPGEYEGDT 129 + GGA I+ F+ +D ++++R+ G +EGDT Sbjct: 96 IAGGAQIFTAFKDDVDTLLVTRLAGSFEGDT 126 Score = 51 (23.2 bits), Expect = 4.8e-10, Sum P(3) = 4.8e-10 Identities = 8/12 (66%), Positives = 10/12 (83%) Query: 12 NRVIGRDGELPW 23 N +IG+DG LPW Sbjct: 10 NGLIGKDGHLPW 21 Score = 46 (20.9 bits), Expect = 4.8e-10, Sum P(3) = 4.8e-10 Identities = 9/26 (34%), Positives = 16/26 (61%) Query: 26 IPADKKQYRSRIADDPVVLGRTTFES 51 +P D +R++ +V+GR T+ES Sbjct: 23 LPDDLHYFRAQTVGKIMVVGRRTYES 48 Score = 34 (15.5 bits), Expect = 0.0034, Sum P(3) = 0.0034 Identities = 6/13 (46%), Positives = 10/13 (76%) Query: 103 AAIYALFQPHLDR 115 AA++A + HLD+ Sbjct: 80 AAVFAYAKQHLDQ 92 sp|P10167|DYRB_STAAU DIHYDROFOLATE REDUCTASE TYPE I. pir||S32014 dihydrofolate reductase (EC 1.5.1.3) - Staphylococcus aureus gi|49313 (Z16422) dihydrofolate reductase [Staphylococcus aureus] Length = 159 Score = 64 (29.1 bits), Expect = 9.2e-10, Sum P(3) = 9.2e-10 Identities = 9/35 (25%), Positives = 21/35 (60%) Query: 98 YVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 ++ GG ++ +D M ++ + G++ GDT++P Sbjct: 91 FIFGGQTLFEEMIDKVDDMYITVIEGKFRGDTFFP 125 Score = 63 (28.6 bits), Expect = 9.2e-10, Sum P(3) = 9.2e-10 Identities = 13/40 (32%), Positives = 21/40 (52%) Query: 26 IPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMS 65 +P D K + +V+GR TFES+ LP +V++ Sbjct: 25 LPNDLKHVKKLSTGHTLVMGRKTFESIGKPLPNRRNVVLT 64 Score = 43 (19.6 bits), Expect = 9.2e-10, Sum P(3) = 9.2e-10 Identities = 10/23 (43%), Positives = 13/23 (56%) Query: 1 MELVSVAALAENRVIGRDGELPW 23 M L + A RVIG + +LPW Sbjct: 1 MTLSILVAHDLQRVIGFENQLPW 23 gi|950041 (Z50804) dihydrofolate reductase type Ib [Escherichia coli] Length = 157 Score = 55 (25.0 bits), Expect = 1.2e-09, Sum P(4) = 1.2e-09 Identities = 13/34 (38%), Positives = 17/34 (50%) Query: 99 VIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 V GG IY P + LS + E EGD ++P Sbjct: 96 VSGGGEIYRETLPMASTLHLSTIDIEPEGDVFFP 129 Score = 46 (20.9 bits), Expect = 1.2e-09, Sum P(4) = 1.2e-09 Identities = 9/23 (39%), Positives = 15/23 (65%) Query: 1 MELVSVAALAENRVIGRDGELPW 23 M++ +AA +N VIG ++PW Sbjct: 1 MKVSLIAAKRKNGVIGCGPDIPW 23 Score = 42 (19.1 bits), Expect = 1.2e-09, Sum P(4) = 1.2e-09 Identities = 14/47 (29%), Positives = 20/47 (42%) Query: 56 LPGSAQIVMSRSERSFSVDTAHRAASVEEAVDIAASLDAETAYVIGG 102 LP V++RS + + D S+EEA+D A GG Sbjct: 54 LPNRKYAVVTRSGWTSNDDNVVVFQSIEEAMDRLAEFTGHVIVSGGG 100 Score = 38 (17.3 bits), Expect = 1.2e-09, Sum P(4) = 1.2e-09 Identities = 7/11 (63%), Positives = 10/11 (90%) Query: 42 VVLGRTTFESM 52 +++GR TFESM Sbjct: 41 LLVGRKTFESM 51 sp|P00380|DYR_ENTFC DIHYDROFOLATE REDUCTASE. pir||RDSODF dihydrofolate reductase (EC 1.5.1.3) - Enterococcus faecium prf||741860A reductase,dihydrofolate [Enterococcus faecium] Length = 167 Score = 97 (44.1 bits), Expect = 2.0e-09, Sum P(2) = 2.0e-09 Identities = 26/105 (24%), Positives = 47/105 (44%) Query: 26 IPADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMSRSERSFSVDTAHRAASVEEA 85 +P D + +R D +V+GR T+E M I++ +++ F V+ + Sbjct: 24 LPNDMRFFREHTMDKILVMGRKTYEGMGKLSLPYRHIIVLTTQKDFKVEKNAEVLHSIDE 83 Query: 86 VDIAASLDAETAYVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTY 130 + A E YV GG+ I+ P + + + E+EGDT+ Sbjct: 84 LLAYAKDIPEDIYVSGGSRIFQALLPETKIIWRTLIDAEFEGDTF 128 Score = 54 (24.6 bits), Expect = 2.0e-09, Sum P(2) = 2.0e-09 Identities = 10/20 (50%), Positives = 15/20 (75%) Query: 4 VSVAALAENRVIGRDGELPW 23 +S+ A +N +IG+DG LPW Sbjct: 3 ISMWAQDKNGLIGKDGLLPW 22 pir||RDLBD dihydrofolate reductase (EC 1.5.1.3) - Lactobacillus casei prf||0309272A reductase,dihydrofolate [Lactobacillus casei] Length = 162 Score = 75 (34.1 bits), Expect = 2.6e-09, Sum P(3) = 2.6e-09 Identities = 12/31 (38%), Positives = 22/31 (70%) Query: 99 VIGGAAIYALFQPHLDRMVLSRVPGEYEGDT 129 + GGA I+ F+ +D ++++R+ G +EGDT Sbjct: 96 IAGGAQIFTAFKDDVDTLLVTRLAGSFEGDT 126 Score = 47 (21.4 bits), Expect = 2.6e-09, Sum P(3) = 2.6e-09 Identities = 7/10 (70%), Positives = 9/10 (90%) Query: 14 VIGRDGELPW 23 +IG+DG LPW Sbjct: 12 LIGKDGHLPW 21 Score = 46 (20.9 bits), Expect = 2.6e-09, Sum P(3) = 2.6e-09 Identities = 9/26 (34%), Positives = 16/26 (61%) Query: 26 IPADKKQYRSRIADDPVVLGRTTFES 51 +P D +R++ +V+GR T+ES Sbjct: 23 LPDDLHYFRAQTVGKIMVVGRRTYES 48 Score = 34 (15.5 bits), Expect = 0.014, Sum P(3) = 0.014 Identities = 6/13 (46%), Positives = 10/13 (76%) Query: 103 AAIYALFQPHLDR 115 AA++A + HLD+ Sbjct: 80 AAVFAYAKQHLDQ 92 pir||A24036 dihydrofolate reductase (EC 1.5.1.3) - Lactobacillus casei Length = 162 Score = 75 (34.1 bits), Expect = 2.6e-09, Sum P(3) = 2.6e-09 Identities = 12/31 (38%), Positives = 22/31 (70%) Query: 99 VIGGAAIYALFQPHLDRMVLSRVPGEYEGDT 129 + GGA I+ F+ +D ++++R+ G +EGDT Sbjct: 96 IAGGAQIFTAFKDDVDTLLVTRLAGSFEGDT 126 Score = 47 (21.4 bits), Expect = 2.6e-09, Sum P(3) = 2.6e-09 Identities = 7/10 (70%), Positives = 9/10 (90%) Query: 14 VIGRDGELPW 23 +IG+DG LPW Sbjct: 12 LIGKDGHLPW 21 Score = 46 (20.9 bits), Expect = 2.6e-09, Sum P(3) = 2.6e-09 Identities = 9/26 (34%), Positives = 16/26 (61%) Query: 26 IPADKKQYRSRIADDPVVLGRTTFES 51 +P D +R++ +V+GR T+ES Sbjct: 23 LPDDLHYFRAQTVGKIMVVGRRTYES 48 sp|P00381|DYR_LACCA DIHYDROFOLATE REDUCTASE. Length = 163 Score = 75 (34.1 bits), Expect = 2.8e-09, Sum P(3) = 2.8e-09 Identities = 12/31 (38%), Positives = 22/31 (70%) Query: 99 VIGGAAIYALFQPHLDRMVLSRVPGEYEGDT 129 + GGA I+ F+ +D ++++R+ G +EGDT Sbjct: 97 IAGGAQIFTAFKDDVDTLLVTRLAGSFEGDT 127 Score = 47 (21.4 bits), Expect = 2.8e-09, Sum P(3) = 2.8e-09 Identities = 7/10 (70%), Positives = 9/10 (90%) Query: 14 VIGRDGELPW 23 +IG+DG LPW Sbjct: 13 LIGKDGHLPW 22 Score = 46 (20.9 bits), Expect = 2.8e-09, Sum P(3) = 2.8e-09 Identities = 9/26 (34%), Positives = 16/26 (61%) Query: 26 IPADKKQYRSRIADDPVVLGRTTFES 51 +P D +R++ +V+GR T+ES Sbjct: 24 LPDDLHYFRAQTVGKIMVVGRRTYES 49 Score = 34 (15.5 bits), Expect = 0.014, Sum P(3) = 0.014 Identities = 6/13 (46%), Positives = 10/13 (76%) Query: 103 AAIYALFQPHLDR 115 AA++A + HLD+ Sbjct: 81 AAVFAYAKQHLDQ 93 gi|149540 (M10922) dihydrofolate reductase [Lactobacillus casei] prf||1107232A reductase,dihydrofolate [Lactobacillus casei] Length = 163 Score = 75 (34.1 bits), Expect = 2.8e-09, Sum P(3) = 2.8e-09 Identities = 12/31 (38%), Positives = 22/31 (70%) Query: 99 VIGGAAIYALFQPHLDRMVLSRVPGEYEGDT 129 + GGA I+ F+ +D ++++R+ G +EGDT Sbjct: 97 IAGGAQIFTAFKDDVDTLLVTRLAGSFEGDT 127 Score = 47 (21.4 bits), Expect = 2.8e-09, Sum P(3) = 2.8e-09 Identities = 7/10 (70%), Positives = 9/10 (90%) Query: 14 VIGRDGELPW 23 +IG+DG LPW Sbjct: 13 LIGKDGHLPW 22 Score = 46 (20.9 bits), Expect = 2.8e-09, Sum P(3) = 2.8e-09 Identities = 9/26 (34%), Positives = 16/26 (61%) Query: 26 IPADKKQYRSRIADDPVVLGRTTFES 51 +P D +R++ +V+GR T+ES Sbjct: 24 LPDDLHYFRAQTVGKIMVVGRRTYES 49 sp|P11731|DYRC_ECOLI DIHYDROFOLATE REDUCTASE TYPE I (TRIMETHOPRIM RESISTANCE PROTEIN). pir||S04810 dihydrofolate reductase (EC 1.5.1.3) type V - Escherichia coli plasmid pLMO20 gnl|PID|e15018 (X12868) dhfrV gene product (AA 1-157) [Enterobacteriaceae] Length = 157 Score = 53 (24.1 bits), Expect = 8.6e-08, Sum P(4) = 8.6e-08 Identities = 12/34 (35%), Positives = 17/34 (50%) Query: 99 VIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 V GG IY P + +S + E EGD ++P Sbjct: 96 VSGGGEIYRETLPMASTLHISTIDIEPEGDVFFP 129 Score = 47 (21.4 bits), Expect = 8.6e-08, Sum P(4) = 8.6e-08 Identities = 10/23 (43%), Positives = 15/23 (65%) Query: 1 MELVSVAALAENRVIGRDGELPW 23 M++ +AA A+N VIG +PW Sbjct: 1 MKVSLMAAKAKNGVIGCGPHIPW 23 Score = 38 (17.3 bits), Expect = 8.6e-08, Sum P(4) = 8.6e-08 Identities = 7/11 (63%), Positives = 10/11 (90%) Query: 42 VVLGRTTFESM 52 +++GR TFESM Sbjct: 41 LLVGRKTFESM 51 Score = 34 (15.5 bits), Expect = 8.6e-08, Sum P(4) = 8.6e-08 Identities = 14/47 (29%), Positives = 19/47 (40%) Query: 56 LPGSAQIVMSRSERSFSVDTAHRAASVEEAVDIAASLDAETAYVIGG 102 LP V++RS + D S+EEA+ A L GG Sbjct: 54 LPNRKYAVVTRSAWTADNDNVIVFPSIEEAMYGLAELTDHVIVSGGG 100 prf||1905364A dihydrofolate reductase:ISOTYPE=VI [Homo sapiens] Length = 157 Score = 54 (24.6 bits), Expect = 8.6e-08, Sum P(4) = 8.6e-08 Identities = 10/23 (43%), Positives = 17/23 (73%) Query: 1 MELVSVAALAENRVIGRDGELPW 23 M++ +AA++EN VIG ++PW Sbjct: 1 MKISLMAAVSENGVIGSGLDIPW 23 Score = 49 (22.3 bits), Expect = 8.6e-08, Sum P(4) = 8.6e-08 Identities = 11/35 (31%), Positives = 16/35 (45%) Query: 98 YVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 +V GG IY D + LS + GD ++P Sbjct: 95 FVSGGGEIYKALIDQADVIHLSVIHKHISGDVFFP 129 Score = 35 (15.9 bits), Expect = 8.6e-08, Sum P(4) = 8.6e-08 Identities = 6/11 (54%), Positives = 10/11 (90%) Query: 42 VVLGRTTFESM 52 +++GR TF+SM Sbjct: 41 LLVGRKTFDSM 51 Score = 34 (15.5 bits), Expect = 8.6e-08, Sum P(4) = 8.6e-08 Identities = 10/36 (27%), Positives = 18/36 (50%) Query: 69 RSFSVDTAHRAASVEEAVDIAASLDAETAYVIGGAA 104 R ++V T + S + V AS+++ AY+ A Sbjct: 57 RKYAVVTRSKIISNDPDVVYFASVESALAYLNNATA 92 sp|P00378|DYR_CHICK DIHYDROFOLATE REDUCTASE. pir||RDCHD dihydrofolate reductase (EC 1.5.1.3) - chicken pdb|8DFR| Dihydrofolate Reductase (E.C.1.5.1.3) pdb|1DR1| Dihydrofolate Reductase (E.C.1.5.1.3) Complex With Nadp+ And Biopterin pdb|1DR2| Dihydrofolate Reductase (E.C.1.5.1.3) Complex With Oxidized Thionicotinamide Adenine Dinucleotide Phosphate pdb|1DR3| Dihydrofolate Reductase (E.C.1.5.1.3) Complex With Oxidized Thionicotinamide Adenine Dinucleotide Phosphate And Biopterin pdb|1DR4| Dihydrofolate Reductase (E.C.1.5.1.3) With Cys 11 Modified With Methyl Mercury Complex With Nicotinamide Adenine Dinucleotide Phosphate And Biopterin pdb|1DR5| Dihydrofolate Reductase (E.C.1.5.1.3) With Cys 11 Modified With Methyl Mercury Complex With Nicotinamide Adenine Dinucleotide Phosphate pdb|1DR6| Dihydrofolate Reductase (E.C.1.5.1.3) With Cys 11 Covalently Bound To Mercuribenzoate Complex With Nicotinamide Adenine Dinucleotide Phosphate And Biopterin pdb|1DR7| Dihydrofolate Reductase (E.C.1.5.1.3) With Cys 11 Covalently Bound To Mercuribenzoate Complex With Nicotinamide Adenine Dinucleotide Phosphate Length = 189 Score = 75 (34.1 bits), Expect = 9.7e-08, Sum P(3) = 9.7e-08 Identities = 13/32 (40%), Positives = 21/32 (65%) Query: 3 LVSVAALAENRVIGRDGELPWPSIPADKKQYR 34 L S+ A+ +N IG+DG LPWP + + K ++ Sbjct: 4 LNSIVAVCQNMGIGKDGNLPWPPLRNEYKYFQ 35 Score = 52 (23.6 bits), Expect = 9.7e-08, Sum P(3) = 9.7e-08 Identities = 9/26 (34%), Positives = 18/26 (69%) Query: 107 ALFQPHLDRMVLSRVPGEYEGDTYYP 132 A+ +P R+ ++R+ E+E DT++P Sbjct: 124 AMEKPINHRLFVTRILHEFESDTFFP 149 Score = 35 (15.9 bits), Expect = 9.7e-08, Sum P(3) = 9.7e-08 Identities = 4/12 (33%), Positives = 9/12 (75%) Query: 95 ETAYVIGGAAIY 106 + +++GG A+Y Sbjct: 110 DMVWIVGGTAVY 121 Score = 35 (15.9 bits), Expect = 0.16, Sum P(3) = 0.14 Identities = 7/19 (36%), Positives = 10/19 (52%) Query: 19 GELPWPSIPADKKQYRSRI 37 G+ W SIP + + RI Sbjct: 53 GKKTWFSIPEKNRPLKDRI 71 sp|P45350|DRTS_DAUCA DIHYDROFOLATE REDUCTASE / THYMIDYLATE SYNTHASE (DHFR-TS). pir||S32242 dihydrofolate reductase (EC 1.5.1.3) / thymidylate synthase (EC 2.1.1.45) - carrot pir||S35272 dihydrofolate reductase (EC 1.5.1.3) / thymidylate synthase (EC 2.1.1.45) - carrot gi|288615 (Z17306) dihydrofolate reductase-thymidylate synthetase [Daucus carota] Length = 528 Score = 58 (26.4 bits), Expect = 3.1e-07, Sum P(5) = 3.1e-07 Identities = 10/18 (55%), Positives = 13/18 (72%) Query: 6 VAALAENRVIGRDGELPW 23 V A +N IG+DG+LPW Sbjct: 27 VVAATQNMGIGKDGKLPW 44 Score = 38 (17.3 bits), Expect = 3.1e-07, Sum P(5) = 3.1e-07 Identities = 7/15 (46%), Positives = 9/15 (60%) Query: 92 LDAETAYVIGGAAIY 106 + E +VIGG IY Sbjct: 128 VSVEKVFVIGGGQIY 142 Score = 35 (15.9 bits), Expect = 3.1e-07, Sum P(5) = 3.1e-07 Identities = 8/26 (30%), Positives = 13/26 (50%) Query: 107 ALFQPHLDRMVLSRVPGEYEGDTYYP 132 AL P D + ++ + E DT+ P Sbjct: 145 ALNAPGCDAVHITEIEEHIECDTFIP 170 Score = 35 (15.9 bits), Expect = 3.1e-07, Sum P(5) = 3.1e-07 Identities = 6/11 (54%), Positives = 10/11 (90%) Query: 42 VVLGRTTFESM 52 V++GR T+ES+ Sbjct: 69 VIMGRKTWESI 79 Score = 34 (15.5 bits), Expect = 3.1e-07, Sum P(5) = 3.1e-07 Identities = 6/12 (50%), Positives = 9/12 (75%) Query: 56 LPGSAQIVMSRS 67 LPG +V++RS Sbjct: 86 LPGRLNVVLTRS 97 pir||A49788 dihydrofolate reductase (EC 1.5.1.3) type IX, trimethoprim-resistant - Escherichia coli plasmid pCJO01 gi|41271 (X57730) dihydrofolate reductase [Escherichia coli] Length = 177 Score = 71 (32.3 bits), Expect = 4.3e-07, Sum P(3) = 4.3e-07 Identities = 13/41 (31%), Positives = 25/41 (60%) Query: 27 PADKKQYRSRIADDPVVLGRTTFESMRDDLPGSAQIVMSRS 67 P D K +++ + +++GR TF S+ LPG +V+S++ Sbjct: 27 PEDLKHFKAVTMNSVLIMGRKTFASLPKVLPGRLHVVVSKT 67 Score = 53 (24.1 bits), Expect = 4.3e-07, Sum P(3) = 4.3e-07 Identities = 11/32 (34%), Positives = 19/32 (59%) Query: 98 YVIGGAAIYALFQPHLDRMVLSRVPGEYEGDT 129 +VIGG + Y ++D++ L+RV + DT Sbjct: 103 FVIGGKSAYENLAAYVDKLYLTRVQLNTQQDT 134 Score = 33 (15.0 bits), Expect = 4.3e-07, Sum P(3) = 4.3e-07 Identities = 5/18 (27%), Positives = 11/18 (61%) Query: 6 VAALAENRVIGRDGELPW 23 + A+ + IG + ++PW Sbjct: 7 IVAVNKTGGIGFENQIPW 24 pir||RDHY75 dihydrofolate reductase (EC 1.5.1.3) (cell line DC-3F/A75) - Chinese hamster Length = 186 Score = 68 (30.9 bits), Expect = 8.6e-07, Sum P(3) = 8.6e-07 Identities = 10/29 (34%), Positives = 21/29 (72%) Query: 6 VAALAENRVIGRDGELPWPSIPADKKQYR 34 + A+++N IG++G+LPWP + + K ++ Sbjct: 7 IVAVSQNHGIGKNGDLPWPMLRNEFKYFQ 35 Score = 55 (25.0 bits), Expect = 8.6e-07, Sum P(3) = 8.6e-07 Identities = 10/26 (38%), Positives = 18/26 (69%) Query: 107 ALFQPHLDRMVLSRVPGEYEGDTYYP 132 A+ QP R+ ++R+ E+E DT++P Sbjct: 124 AMNQPGHLRLFVTRIMQEFESDTFFP 149 Score = 34 (15.5 bits), Expect = 0.15, Sum P(3) = 0.14 Identities = 7/19 (36%), Positives = 9/19 (47%) Query: 19 GELPWPSIPADKKQYRSRI 37 G W SIP + + RI Sbjct: 53 GRKTWFSIPEKNRPLKDRI 71 Score = 33 (15.0 bits), Expect = 8.6e-07, Sum P(3) = 8.6e-07 Identities = 3/12 (25%), Positives = 10/12 (83%) Query: 95 ETAYVIGGAAIY 106 + +++GG+++Y Sbjct: 110 DMVWIVGGSSVY 121 Score = 32 (14.5 bits), Expect = 0.14, Sum P(2) = 0.13 Identities = 6/19 (31%), Positives = 11/19 (57%) Query: 57 PGSAQIVMSRSERSFSVDT 75 PG ++ ++R + F DT Sbjct: 128 PGHLRLFVTRIMQEFESDT 146 sp|P13955|DYRA_STAAU DIHYDROFOLATE REDUCTASE TYPE I (TN4003). pir||S04164 dihydrofolate reductase (EC 1.5.1.3) - Staphylococcus aureus plasmid pSK1 transposon Tn4003 pir||S10715 dihydrofolate reductase (EC 1.5.1.3) type S1 - Staphylococcus aureus gi|46553 (Y07536) dihydrofolate reductase type S1 [Staphylococcus aureus] gi|46750 (X13290) S1 DHFR (AA 1-161) [Staphylococcus aureus] Length = 161 Score = 73 (33.2 bits), Expect = 9.9e-07, Sum P(3) = 9.9e-07 Identities = 10/35 (28%), Positives = 22/35 (62%) Query: 98 YVIGGAAIYALFQPHLDRMVLSRVPGEYEGDTYYP 132 ++ GG +Y +D M ++ + G+++GDT++P Sbjct: 91 FIFGGQTLYEAMIDQVDDMYITVIDGKFQGDTFFP 125 Score = 48 (21.8 bits), Expect = 9.9e-07, Sum P(3) = 9.9e-07 Identities = 10/23 (43%), Positives = 13/23 (56%) Query: 1 MELVSVAALAENRVIGRDGELPW 23 M L + A + RVIG +LPW Sbjct: 1 MTLSIIVAHDKQRVIGYQNQLPW 23 Score = 32 (14.5 bits), Expect = 9.9e-07, Sum P(3) = 9.9e-07 Identities = 8/22 (36%), Positives = 13/22 (59%) Query: 72 SVDTAHRAASVEEAVDIAASLD 93 +V ++A+ E VD+ SLD Sbjct: 60 NVVLTNQASFHHEGVDVINSLD 81 pir||S13096 dihydrofolate reductase (EC 1.5.1.3), methotrexate-resistant - mouse Length = 187 Score = 67 (30.5 bits), Expect = 1.3e-06, Sum P(3) = 1.3e-06 Identities = 10/29 (34%), Positives = 21/29 (72%) Query: 6 VAALAENRVIGRDGELPWPSIPADKKQYR 34 + A+++N IG++G+LPWP + + K ++ Sbjct: 8 IVAVSQNMGIGKNGDLPWPPLRNEWKYFQ 36 Score = 55 (25.0 bits), Expect = 1.3e-06, Sum P(3) = 1.3e-06 Identities = 10/26 (38%), Positives = 18/26 (69%) Query: 107 ALFQPHLDRMVLSRVPGEYEGDTYYP 132 A+ QP R+ ++R+ E+E DT++P Sbjct: 125 AMNQPGHLRLFVTRIMQEFESDTFFP 150 Score = 34 (15.5 bits), Expect = 0.15, Sum P(3) = 0.14 Identities = 7/19 (36%), Positives = 9/19 (47%) Query: 19 GELPWPSIPADKKQYRSRI 37 G W SIP + + RI Sbjct: 54 GRKTWFSIPEKNRPLKDRI 72 Score = 33 (15.0 bits), Expect = 1.3e-06, Sum P(3) = 1.3e-06 Identities = 3/12 (25%), Positives = 10/12 (83%) Query: 95 ETAYVIGGAAIY 106 + +++GG+++Y Sbjct: 111 DMVWIVGGSSVY 122 Score = 32 (14.5 bits), Expect = 0.20, Sum P(2) = 0.18 Identities = 6/19 (31%), Positives = 11/19 (57%) Query: 57 PGSAQIVMSRSERSFSVDT 75 PG ++ ++R + F DT Sbjct: 129 PGHLRLFVTRIMQEFESDT 147 gi|304502 (M19869) dihydrofolate reductase (EC 1.5.1.3) [Cricetulus sp.] Length = 187 Score = 67 (30.5 bits), Expect = 1.3e-06, Sum P(3) = 1.3e-06 Identities = 10/29 (34%), Positives = 21/29 (72%) Query: 6 VAALAENRVIGRDGELPWPSIPADKKQYR 34 + A+++N IG++G+LPWP + + K ++ Sbjct: 8 IVAVSQNMGIGKNGDLPWPMLRNEFKYFQ 36 Score = 55 (25.0 bits), Expect = 1.3e-06, Sum P(3) = 1.3e-06 Identities = 10/26 (38%), Positives = 18/26 (69%) Query: 107 ALFQPHLDRMVLSRVPGEYEGDTYYP 132 A+ QP R+ ++R+ E+E DT++P Sbjct: 125 AMNQPGHLRLFVTRIMQEFESDTFFP 150 Score = 34 (15.5 bits), Expect = 0.15, Sum P(3) = 0.14 Identities = 7/19 (36%), Positives = 9/19 (47%) Query: 19 GELPWPSIPADKKQYRSRI 37 G W SIP + + RI Sbjct: 54 GRKTWFSIPEKNRPLKDRI 72 Score = 33 (15.0 bits), Expect = 1.3e-06, Sum P(3) = 1.3e-06 Identities = 3/12 (25%), Positives = 10/12 (83%) Query: 95 ETAYVIGGAAIY 106 + +++GG+++Y Sbjct: 111 DMVWIVGGSSVY 122 Score = 32 (14.5 bits), Expect = 0.20, Sum P(2) = 0.18 Identities = 6/19 (31%), Positives = 11/19 (57%) Query: 57 PGSAQIVMSRSERSFSVDT 75 PG ++ ++R + F DT Sbjct: 129 PGHLRLFVTRIMQEFESDT 147 gi|387160 (J00388) dihydrofolate reductase ( [Mus musculus] gi|439209 (L26316) dihydrofolate reductase [Mus musculus] Length = 187 Score = 67 (30.5 bits), Expect = 1.3e-06, Sum P(3) = 1.3e-06 Identities = 10/29 (34%), Positives = 21/29 (72%) Query: 6 VAALAENRVIGRDGELPWPSIPADKKQYR 34 + A+++N IG++G+LPWP + + K ++ Sbjct: 8 IVAVSQNMGIGKNGDLPWPPLRNEFKYFQ 36 Score = 55 (25.0 bits), Expect = 1.3e-06, Sum P(3) = 1.3e-06 Identities = 10/26 (38%), Positives = 18/26 (69%) Query: 107 ALFQPHLDRMVLSRVPGEYEGDTYYP 132 A+ QP R+ ++R+ E+E DT++P Sbjct: 125 AMNQPGHLRLFVTRIMQEFESDTFFP 150 Score = 34 (15.5 bits), Expect = 0.15, Sum P(3) = 0.14 Identities = 7/19 (36%), Positives = 9/19 (47%) Query: 19 GELPWPSIPADKKQYRSRI 37 G W SIP + + RI Sbjct: 54 GRKTWFSIPEKNRPLKDRI 72 Score = 33 (15.0 bits), Expect = 1.3e-06, Sum P(3) = 1.3e-06 Identities = 3/12 (25%), Positives = 10/12 (83%) Query: 95 ETAYVIGGAAIY 106 + +++GG+++Y Sbjct: 111 DMVWIVGGSSVY 122 Score = 32 (14.5 bits), Expect = 0.20, Sum P(2) = 0.18 Identities = 6/19 (31%), Positives = 11/19 (57%) Query: 57 PGSAQIVMSRSERSFSVDT 75 PG ++ ++R + F DT Sbjct: 129 PGHLRLFVTRIMQEFESDT 147
You can look at the
references
or the
Quadratic Logistic Algorithm
Last updated : 1/20/2000